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For the calculation of the volumetric overlap between two voxel sets several methods exist  where the most frequently used are Dice coefficient (DC)  which is also called volume overlap index  DC 2(|SB S ̃A|)| S B | | S ̃ A | Jaccard coefficient (JC) or volumetric overlap (VO)  J C V O | S B S ̃ A || S B S ̃ A | which can also be alternatively calculated as  J C | S B | | S ̃ A | 1(8.
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