9 (left, upper panel) shows the secretion profile obtained by deconvolution from plasma C-peptide data (left, bot- tom panel) using the C-peptide impulse response. Very similar observations were made in a recent study with a transgenic mouse carrying a RARE-galactosidase reporter construct that is activated by endogenous retinoids (17); the authors found that strong -galactosidase activity (and hence high retinoid content) was present in perichondrial tissues adjacent to the prehypertrophic and hypertrophic zones of long bone growth plate as well as in hypertrophic cartilage itself.
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